General Pharmacology Course

Pharmacokinetics AND Pharmacodynamics….10 Videos + 10 Handwritten Notes + >25 Questions and Answers + PUN (Downloadable instantly).

— With your download comes a Google Drive Link that you can use to stream/watch the videos, including at 1.5X or 2X speed —

Note: This course has tons of Mathematical Graphs and Equations :O

but don’t worry, with Medicosis, and the help of several problems and solutions (Q&A), everything will make perfect sense :)

Topics discussed in this course include:

FIRST: PHARMACOKINETICS

• Routes of Administration (Pros and Cons of each).

• Absorption (and the factors that affect it)

  • Bioavailability (BA)

  • Bioequivalence (BE)

  • First-Pass Metabolism (First-Pass Hepatic Effect)

  • PK and PH (Acids, Bases, Ionized, Non-ionized, Protonated, Non-protonated, Lipid-soluble, Water-soluble)

  • The Henderson-Haselbalch Equation.

  • Filtration, Absorption, and Secretion.

• Distribution and Redistribution (and the clinical implications).

  • Volume of Distribution

  • The blood brain barrier (BBB) and the placental barrier.

  • Ion Trapping (and how it can be fatal)

  • Fick Principle.

• Metabolism (Biotransformation)

  • 3 phases of Metabolism:

    • Modification (Oxidation, Reduction & Hydrolysis)

    • Conjugation (Acetylation, Methylation, Glutathionylation, Glucourinidation & Sulfation)

    • Drug Transporters.

  • The P450 System (Liver Microsomal Enzymes).

    • CYP3A4, CYP2D6, CYP1A2, CYP2C9, CYP2C19, CYP2EI

    • Genetic Polymorphism

• Elimination (Excretion of the Drug)

  • Zero-order elimination (and why it’s dangerous)

  • First-order elimination.

    • Comparison between the two.

  • Exponential (Geometric) Graphs vs Linear (Arithmetic) Graphs.

  • Half-Life

  • The Elimination Constant (K)

  • The Elimination Curve and the Concentration at Time Zero (an extrapolation)

SECOND: PHARMACODYNAMICS:

• LDR Curves (Log-Dose Response Curves)

• Efficacy

• Potency

• Agonists (Full Agonists vs Partial Agonists)

• Antagonists (Competitive, Non-Competitive, Reversible, Irreversible)

• Inverse Agonist (Super Antagonists)

• Cell Receptor Signaling (G-Protein, Receptor Tyrosine Kinase, JAK-STAT, Non-receptor Tyrosine Kinase, Calmodulin).

• Stereospecificity, Adverse Effects, Teratogenicity.

• FDA (Government) regulations.

Again, This course has tons of Mathematical Graphs and Equations :O

but don’t worry, with Medicosis, and the help of several problems and solutions (Q&A), everything will make perfect sense :)

-—> Scroll down to watch the first 60 minutes for FREE!